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Navlimetostat hydrochloride is a research-grade small-molecule inhibitor selective for the PRMT5-MTA complex. It demonstrates potent biochemical and cellular activity and is used in preclinical studies to probe PRMT5 biology and evaluate antineoplastic effects, with reported selectivity in MTAP-deleted models.
Potent inhibitor of the PRMT5-MTA complex (IC50 3.6 nM).
Inhibits PRMT5 enzymatic activity (IC50 20.5 nM).
Shows cellular selectivity in MTAP-deleted models (cell viability 12 nM vs 890 nM in parental cells).
High purity (99.2%).
Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
Suitable for preclinical research; store sealed away from moisture.
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Vardenafil-d5 (hydrochloride) is a laboratory chemical primarily used for the manufacture of substances. This product is strictly for research use only by experienced personnel and has not been fully validated for medical applications.
Purity of 98.7% by LCMS
Isotopic enrichment of 99.8%
Appears as a white to off-white solid
Molecular formula: C23H28D5ClN6O4S
Molecular weight: 530.09
Store powder at -20°C for up to 3 years or 4°C for up to 2 years
Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month
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Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor that effectively lowers intraocular pressure. This beta blocker is primarily utilized for glaucoma research, providing a clear solution for studies involving eye pressure regulation.
Appearance: solid
Color: white to off-white
Molecular weight: 343.89
Formula: C18H30ClNO3
For research use only
Soluble in DMSO and H2O
Recommended storage at 4°C, sealed, away from moisture. In solvent, -80°C for 6 months, -20°C for 1 month.
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Mindeudesivir hydrobromide (VV116) is a deuterated version of Remdesivir, a highly orally active nucleoside antiviral agent against SARS-CoV-2 and respiratory syncytial virus (RSV). It maintains the antiviral activity of Remdesivir against COVID-19 and is noted as the first domestically produced deuterium targeting COVID-19. Deuteration can affect the pharmacokinetic and metabolic profiles of drugs, potentially offering several advantages.
Used as a tracer or internal standard for quantitative analysis.
Extends in vivo half-life and improves oral bioavailability.
Improves metabolic characteristics and drug safety.
Preserves therapeutic properties.
Inhibits RSV replication in A549 cells.
Shows strong antiviral activity against RSV in mice.
Exhibits favorable pharmacokinetic properties and good safety profile.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More